Bisacodyl is a diphenyl acetic acid that directly affects the nerve endings of the mucous membrane and submucosa of the rectum of the large intestine. Has a laxative effect. Stimulates intestinal peristalsis, inhibits the absorption of electrolytes, increasing the water content in feces, causing a liquefaction of feces and facilitating stool. Defecation occurs approximately 30-60 minutes after rectal administration and 6-12 hours after oral administration. The drug is metabolized by enzymes of the colon mucosa to form the pharmacologically active form of diphenol (BHPM), which is conjugated with glucuronic and sulfuric acid. Bisacodyl is almost not absorbed into the systemic circulation; after absorption, the drug undergoes deacetylation in the liver to form a phenyl derivative and is excreted in the urine. The remaining part of the drug in the colon is excreted in the feces.

Bisacodyl: indications for use

Short-term symptomatic treatment of constipation, including chronic constipation in bedridden patients and in the elderly. Also used in preparation for diagnostic procedures, surgical and obstetric operations.

Bisacodyl: contraindications

Hypersensitivity to any of the components of the drug, abdominal pain, nausea or vomiting for unexplained reasons, especially if they indicate the presence of an acute illness in the abdominal cavity, for example, appendicitis, intestinal obstruction, colitis, Crohn's disease, gastrointestinal bleeding, severe dehydration ... The drug in the form of suppositories should not be used for anal fissures or ulcerative hemorrhoids, due to the risk of irritation or pain. It is not recommended to use the drug in newborns. Long-term and regular use of bisacodyl should be avoided, as this leads to increased constipation, as well as to disturbances in water and electrolyte balance, including hypokalemia. If the daily use of laxatives is necessary, the cause of the constipation should be determined. Cases of dizziness and / or fainting during bowel movements have been reported in patients taking laxatives, but it is not known whether they are associated with straining during bowel movements or with a neurovascular reflex caused by pain in constipation. Some patients may have blood in their stools; the bleeding is insignificant and self-limiting. In the case of frequent use of the drug in the elderly, there may be an increase in weakness, the development of orthostatic hypotension, and coordination disorders associated with the loss of electrolytes.

Interaction with other drugs

Bisacodyl increases the kaliuretichesky effect of diuretics and glucocorticoids. Long-term use of bisacodyl can lead to a decrease in serum potassium levels and a secondary increase in the effects of digitalis glycosides. Milk, antacids and proton pump inhibitors reduce the effect of oral bisacodyl and increase the risk of irritation of the stomach lining; these drugs or milk should be taken one hour before taking bisacodyl or one hour after taking it.

Bisacodyl: side effects

Often: abdominal cramps, abdominal pain, diarrhea, nausea; not very often: discomfort in the abdomen or around the anus, vomiting, blood in the stool, dizziness; rarely: hypersensitivity reactions, fainting, Quincke's edema, anaphylactic reactions, dehydration, colitis. Symptoms of an acute overdose may include diarrhea, intestinal cramps, abdominal pain, and clinically significant loss of fluid and electrolytes (especially potassium). In order to reduce the absorption of the drug, induce vomiting or gastric lavage; the drug has no specific antidote; in case of poisoning, symptomatic treatment is used, first of all, the alignment of the water-electrolyte balance, the use of antispasmodics. Long-term use can lead to the development of chronic diarrhea, abdominal pain, hypokalemia, secondary hyperaldosteronism, kidney stones and addiction; hypokalemia can lead to renal tubular damage, metabolic alkalosis, and muscle weakness. In rare cases, the drug can cause intestinal atony and chronic proctitis.

Pregnancy and lactation

Category B. There is insufficient data on use during pregnancy; the use of the drug during pregnancy is not recommended. Bizacodyl and its glucuronic derivatives do not pass into breast milk; not recommended for use during lactation.

Bisacodyl: instruction

The tablets should be swallowed whole without chewing, the most effective is a single dose at bedtime or 30 minutes before breakfast; candles are best used in the morning. Constipation. Adults. 5–10 mg 1 × / day orally or 10 mg 1 × / day rectally. Children over 10 years old. Oral 5–10 mg 1 × / day. Children 4–10 years of age 5 mg 1 × / day. Bowel cleansing before diagnostic tests and surgical procedures. Adults and children over 10 years of age: 10 mg orally in the morning and 10 mg in the evening, the day before the examination or surgery; usually it is recommended to additionally use bisacodyl in the form of suppositories on the morning of the examination or surgery. Children 4–10 years old: 5 mg in the evening the day before examination or surgery; according to some sources, additional use of bisacodyl in the form of suppositories is recommended on the morning of the examination or surgery.

In this medical article, you can read the drug Bisacodyl. The instructions for use will explain in which cases you can take suppositories or tablets, what the medicine helps from, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can leave only real reviews about Bisacodyl, from which it is possible to find out whether the medicine has helped in the treatment of constipation and stool regulation in adults and children, for which it is also prescribed. The instructions list the analogues of Bisacodyl, the prices of the drug in pharmacies, as well as its use during pregnancy.

Bisacodyl is a synthetic laxative drug that acts primarily in the large intestine. Instruction for use informs that Hemofarm 5 mg tablets, 10 mg suppositories irritate the intestinal mucosa, thus creating a therapeutic effect.

Release form and composition

Dosage forms of Bisacodyl:

• Enteric-coated tablets (30 pcs. In blisters, 1 blister in a carton box).
• Rectal suppositories (3 or 5 pcs. In blisters, 2 blisters in a carton box).

The main active ingredient is bisacodyl:

• 1 tablet - 5 mg;
• 1 suppository - 10 mg.

pharmachologic effect

Bisacodyl has a laxative effect. The active substance of the drug contributes to:

• Softening or liquefaction of feces, which occurs by increasing the excretion of water and electrolytes into the intestines and at the same time reducing their absorption.
• Acceleration of intestinal motility and an increase in the production of mucus in the large intestine, which is due to the irritating effect of the active substance on its mucous membrane.

The laxative effect is observed after 8-12 hours (subject to use before bedtime), after 6 hours (subject to taking the drug in the morning), within 15-45 minutes (subject to rectal suppositories).

Indications for use

What does Bisacodyl help from? Suppositories and tablets are prescribed if the patient has:

• constipation, which is caused by hypotension and low motility of the large intestine in the elderly, in the postoperative or postpartum period, with a diet;
• violation of the act of defecation of unknown etiology;
• preparation for surgery;
• bowel studies using instrumental or endoscopic means;
• regulation of bowel emptying for hemorrhoids, inflammation of the rectum, fissures in the anal and perianal region.

Instructions for use

Drink before bedtime or 30 minutes before breakfast:

• adults and children over 14 years old - 5-15 mg;
• children 8-14 years old - 5-10 mg;
• children 3-7 years old - 5 mg.

The tablets are swallowed without chewing and with a little water. In preparation for surgical operations, instrumental and X-ray examinations - 10 mg at night one day before and on the eve of the operation or study.

Candles

Rectally adults - 10-20 mg, children aged 8-14 years - 10 mg, 2-7 years - 5 mg.

Contraindications

Contraindications to the use of this remedy are as follows: ileus, subileus, problems with water-electrolyte balance, intestinal neoplasms, acute disturbances in the gastrointestinal tract, constipation in case of intestinal polyposis.

Side effects

The use of Bisacodyl can cause allergic reactions, abdominal pain and diarrhea, as a result of which, due to a violation of the water-electrolyte balance, cramps, muscle weakness and arterial hypotension may appear.

Children, during pregnancy and breastfeeding

With caution during pregnancy and lactation. Contraindicated in children under 3 years of age.

special instructions

Treatment with suppositories and Bisacodyl tablets should be short-term (no more than 7-10 days), otherwise the development of intestinal atony is possible, in which, due to the inability to independently carry out the act of defecation, you will need to take stronger laxatives.

Due to the possible occurrence of side effects during the period of use of Bisacodyl, one should refrain from driving vehicles and other work requiring increased concentration.

Drug interactions

Carbenoxolone, Hydrochlorothiazide, Prednisolone, Methylprednisolone, Furosemide, Hydrocortisone and Dexamethasone in combination with Bisacodyl increase the loss of potassium in the body. Accordingly, a deficiency of this trace element may develop.

The combination with antacid drugs, Ranitidine, Cimetidine, Omeprazole reduces the laxative effect and provokes irritation of the gastric mucosa, which is accompanied by severe pain syndrome.

A long course of Bisacodyl, together with cardiac glycosides, enhances the action of the latter. Opiates, cholestyramine, psychotropic and anticholinergic drugs also reduce the effect of the drug.

Analogues of the drug Bisacodyl

Analogs are determined by structure:

1. Laxatin.
2. Laxbene.
3. Bisacodyl Acri (Altpharm, Nizhpharm, FPO, Hemofarm).
4. Dulcolax.

The group of laxatives includes analogues:

1. Portalak.
2. Lavacol.
3. Forteza Rompharm.
4. Musinum.
5. Regulax.
6. Guttasil.
7. Guttalax.
8. Osmogol.
9. Romfalak.
10. Buckthorn extract.
11. Castor oil.
12. Ex Lax.
13. Dulcolax.
14. Lactitol monohydrate.
15. Pursennid.
16. Tritinate.
17. Laxatin.
18. Senna.
19. Lizalak.
20. Buckthorn bark.
21. Kelp.
22. Candles with glycerin.
23. Glaxenna.
24. Vaseline oil.
25. Sennalax.
26. Good luck.
27. Import N.
28. RectActive.
29. Senalex.
30. Centaury herb.
31. Zhostera laxative fruit.
32. Buckthorn syrup.
33. Normase.
34. Duphalac.
35. Norgalax.
36. Senadexin.
37. Fiberlex.
38. Laxigal.
39. Enema Wedge.
40. Licorice root.
41. Weak.
42. Relistor.
43. X Prep.
44. Steel tincture.
45. Dr. Theiss Nova figure.
46. Resolor.
47. Weak up.
48. Depuraflux.
49. Glycelax.
50. Flax seeds.
51. Glycerol.
52. Califig.
53. Herbion Laksana.
54. Lactulose.
55. Tranzipeg.
56. Bekunis dragee.
57. Realaksan.
58. Mucofalk.
59. Klam.
60. Laxbene.
61. Legendal.
62. Tisasen.

Vacation conditions and price

The average cost of Bisacodyl Hemofarm (5 mg tablets No. 30) in Moscow is 25 rubles. The price of candles is 49 rubles for 10 suppositories of 10 mg each. Available without a prescription.

The shelf life of Bisacodyl is 5 years. The storage place should be out of the reach of children, the humidity should not exceed the norm, the temperature should be 15-25 degrees. The storage area must be protected from light. Application after the expiration date is prohibited.

In pursuit of a slim and fit figure, women often resort to very dangerous methods of weight loss. At the same time, lovely ladies forget that not all products are safe for health. Today I would like to talk about such a drug as Bisacodyl Hemofarm, which is used by a large number of women for weight loss.

What is this drug?

Bisacodyl Hemofarm is a laxative. The drug improves the functioning and contraction of the large intestine. In addition, the drug improves the secretion of mucus in the large intestine, which, in turn, envelops the feces and makes it easier for them to escape.

Bisacodyl should be taken by bedridden patients, people after surgery, childbirth and those who suffer from constipation as prescribed by a doctor. The drug is prescribed for use to free the intestines in preparation for surgery or examination, to normalize stool with anal fissures and other problems.

By the way, Bisacodyl tablets and suppositories are considered a fairly strong remedy, which has a number of contraindications.

You cannot use the drug:

• With intestinal obstruction;
• Injured hernia;
• With acute hemorrhoids;
• With uterine bleeding, etc.

The list of contraindications is very, very large, so in order not to cause irreparable harm to health, before using any medicine, consult your doctor.

What about losing weight?

So, if you are wondering how you should take Bisacodyl for weight loss, then it is worth knowing that this method of weight loss is not medical. There is no mention in the instructions for the drug that it helps to get rid of extra pounds.

Bisacodyl for weight loss has become popular with beautiful ladies only due to the fact that there are a huge number of positive reviews on the Internet about weight loss with the help of laxatives. And if we talk about candles and tablets Bisacodyl Hemofarm, then this drug is very affordable, available without a prescription and sold in any pharmacy. So women are experimenting with their health.

Some ladies are on strict diets and, in addition, take bisacodyl tablets to accelerate weight loss. But there are also people who do not want to prejudice themselves in food. They do not change their diet, but they use laxative suppositories or pills. Such manipulations lead to the fact that nutrients that have entered the body with food simply do not have time to penetrate into the blood.

Accordingly, weight loss occurs. A person who started taking laxatives is simply deceiving his body. He does not feel hunger, since food enters the stomach, but at the same time there is no saturation with nutrients, and this is certainly bad.

Is everything so harmless?

Recently, more and more people have begun to use bisacodyl suppositories and diet pills to accelerate weight loss. But this approach is fundamentally wrong. The fact is that this drug cannot be used regularly. It is intended as a one-time relief for constipation. And even then, it is recommended to use it only after consulting a specialist.

If you decide to use laxative tablets or suppositories for weight loss and do it for a long time, then the consequences can be dire. There is a possibility of diarrhea and dehydration.

Of course, from all the manipulations done, you will see weight loss, since all the feces will come out, and the body will lose fluid. But the harm that will be done to the body is difficult to describe.

Think for yourself, frequent bowel movements caused by drugs lead to dehydration and loss of nutrients (mostly potassium). All this will have to be replenished in the future, and it is not easy to do it.

In addition, using Bisacodyl for weight loss, you run the risk of earning dysbiosis, and it will take a long time to treat this disease, and the drugs cost a lot of money.

There is one more point worth noting. Long-term use of Bisacodyl Hemofarm can be addictive. It is strictly forbidden to use this drug for more than 7 days. If you drink a laxative in large doses: 2 tablets or more per day, then addiction can occur after 2-3 days.

Simply put, your intestines will simply forget how to work on their own, its contractions will cease to occur, which means that the feces will not move "towards the exit." You simply cannot defecate without the use of laxatives. Moreover, if you used Bisacodyl for weight loss, then in the future you will have to increase the dose of the medicine in order to simply empty the intestines.

Treatment after such a "light" weight loss will be long and unpleasant. Therefore, doctors strongly recommend not to use any laxative tablets and suppositories for weight loss. In this case, it does not matter at all according to what scheme you will take the drugs. Just be aware that this type of weight loss is hazardous to your health.

In general, dear ladies, if you decide to get rid of extra pounds using laxative tablets or suppositories, then throw this venture out of your head. You will get nothing but health problems from this.

Easily and simply Bisacodyl eliminates excess weight, harmful toxins and toxins. Learn how to take a weight loss drug correctly, how to speed up the onset of the desired effect and lose up to 2 kg per dose!

Bisacodyl belongs to a group of drugs with a strong laxative effect. Almost immediately after the appearance of the drug in pharmacies, in addition to medical prescriptions, they began to actively use it for weight loss, exploiting the laxative effect of the drug. Weight loss after a single use is significant and amounts to about 2-4 kg.

In therapeutic practice, bisacodyl is prescribed one-time, in acute situations and its systematic use is not provided. If, during stagnation in the intestines of feces and toxins, signs of poisoning of the body with toxins begin to appear, then the use of bisacodyl is an emergency measure to solve the problem: settled toxins and toxins are completely eliminated in the shortest possible time. The absence of serious manifestations of toxic poisoning is sufficient reason not to use this laxative, but to look for less aggressive options.

For stable weight loss, a single use is not enough, therefore, in order to reduce weight, this medicine is not used in accordance with the prescribed instructions requirements, but in any form. This approach guarantees weight loss, but provokes a deficiency of nutrients and macronutrients, which negatively affects well-being and health. In the course of losing weight, it is more justified to use a laxative to cleanse the intestines, but only at the first stage of a series of complex measures for losing weight.

Forms of issue

There are two main forms of bisacodyl release: tablets and rectal suppositories. Both of these forms cause irritation of the nerve endings of the mucous epithelium of the small and large intestines, an increase in the secretion of mucus that envelops the feces, which facilitates its excretion (excretion).

Candles

Rectal suppositories "Bisacodyl" are produced in 10 pieces. packaged. The content of the active substance is 10 mg.

To give the required consistency, they contain solid fat (semi-synthetic glycerides). The shape is torpedo-shaped, facilitating the introduction inside. Applied rectally.

The advantage of suppositories is that the use is not associated with time with meals. The introduction is made once a day, the daily rate is 1-2 candles.

With this form, possible irritation of the stomach by the active components of the drug is excluded, which minimizes the possibility of discomfort from the gastrointestinal tract.

Another point that testifies in favor of the use of rectal suppositories: the action time is reduced to one hour, which allows you to get the result 5-7 hours faster in comparison with tablets. The dosage depends on the condition, age, weight and individual characteristics of a person's metabolism.

When using suppositories, painful sensations in the anus are possible.

Pills

Bisacodyl tablets - available in blisters of 6, 12, 24 pcs. or in a plastic container of 30, 50, 100 pcs. in an enteric sugar-containing shell, color - yellow, shape - round, biconvex. The dosage of the active substance is 5 mg.

Shows an effect after 6 hours, and if taken before bedtime - after 8-12 hours.

Operating principle

The formula of the drug is a combination of synthetic chemicals that, getting inside the gastrointestinal tract, undergo a number of changes. In the course of metabolic processes, the action of the main substance is activated: it directly interacts with the receptors of the nerve endings of the intestine, causing irritation of the mucous membrane.

The unique quality of bisacodyl is to significantly enhance peristalsis throughout the intestine. This property allows you to quickly and painlessly promote feces and remove them from the body. The second action is to initiate the production of an increased amount of mucus that envelops the feces, which makes it possible to facilitate bowel movements as much as possible.

In addition to increasing the motility of the gastrointestinal tract, the drug promotes the entry of an increased volume of fluid into the intestine and prevents its reabsorption, which increases the total quantitative composition of excrement. Due to the increased water content, the stool becomes softer and more elastic, which simplifies the act of defecation.

Slimming schemes

There are two options for taking bisacodyl, which are used for the purpose of drastic weight loss.

Option number 1

The use of the drug while adhering to a low-calorie diet. This approach increases the weight loss that is provided by a deficit in dietary calorie intake.

Option number 2

Reception without changing the usual diet. In this case, accelerated excretion reduces the absorption and assimilation of nutrients that enter the body with food.

In both cases, the dosage regimen for Bisacodyl remains the same as in the treatment of constipation.

It is important to remember that if, while taking a laxative, the fat layer begins to decrease, this means that there is a sharp deficit in the supply of mineral and nutrients from the gastrointestinal tract to the blood, which the body is trying to smooth out by processing the internal reserve. This situation is perceived by the body as stressful and leads to a sharp increase in weight after the desired weight loss.

Composition of the preparation

The main active ingredient is bisacodyl, a white crystalline powder (sometimes with a yellowish tinge). It is practically insoluble in water. Inert, not absorbed in the intestine.

To ensure complete and rapid assimilation, the medicine contains a number of excipients:

• lactose monohydrate - 49 mg;
• wheat starch - 40 mg;
• silicon dioxide (colloidal) - 1 mg;
• magnesium stearate - 1 mg;
• talc - 3 mg;
• gelatin - 1 mg;
• witepsol (in suppositories) - 1.20 mg.

The shell contains:

• methacrylic acid - ethyl acrylate copolymer (Eudragit L - 100) - 0.57 mg.
• icing sugar (tablets) - 1.0 mg;
• aerosil - 1 mg;
• titanium dioxide - 0.40 mg;
• quinoline yellow dye - 0.33 mg;
• microcrystalline cellulose - 1 mg;
• low crystalline medical polyvinylpyrrolidone - 1 mg;
• wax - 1 mg;
• talc - 1.57 mg.

Instructions for use

Indications for the use of "Bisacodyl":

• lack of peristalsis and intestinal tone (atony);
• hypotonic constipation;
• constipation in the elderly;
• constipation after childbirth and postoperative;
• to cleanse the intestines in preparation for surgery;
• in preparation for X-ray and endoscopic diagnostic examinations;
• before childbirth (alternative to enema).

How to take it right

The rate of the drug per day is from 5 to 15 mg. It is necessary to start the application with the possible minimum - 5 mg. It is advisable to drink one tablet of bicasodil at night before going to bed. It takes an average of 6 to 8 hours before the onset of the action. During this time, the active substance is transported to the large intestine. If one dose does not bring the desired result, then in the morning you can apply another one. Thus, it is necessary to determine the dose of the drug necessary in a particular case, however, taking more than 20 mg per day is strictly prohibited.

The tablet should be taken with plenty of water, not chewed or broken before use.

In the case of rectal suppositories, the laxative effect appears earlier: from 15 minutes to 1 hour. The suppository should be injected into the rectal area after an enema or spontaneous bowel cleansing 1-2 times a day (morning and evening). Before the introduction, release it from the contour package and insert with a pointed end deep into the rectum to avoid extraction.

Bicasodil for weight loss, in any form, should not be used longer than 5-6 days. If, along with bisacodyl, drugs for heartburn are used, then they must be taken at intervals of at least 180 minutes.

It is important to know that exceeding the dosage of a laxative causes atony of the loops of the large intestine, dehydration and acute deficiency of potassium ions. In order to avoid dehydration, it is recommended to drink heavily throughout the course.

With spastic constipation, the drug can only worsen the situation, so you need to make sure of the etiology of constipation, which is difficult for a person who does not have medical education.

2 hours before taking the medicine and 2 hours after, the intake of dairy products and alkaline mineral water should be avoided, since they change the acid balance of the gastrointestinal tract and weaken the effect of bisacodyl.

This laxative can cause addiction and addiction, which develops quite quickly - in some cases, after 2 days of administration, provoking a chronic form of intestinal atony. This phenomenon is the reason why emptying the intestines on their own (without the use of laxatives) becomes problematic or impossible.

The drug affects the ability to control mechanical vehicles and to maintain devices that are in motion.

Combination with other medicines

It is forbidden to take Bisacodyl concurrently with the following medicines:

• Antacid drugs (to combat heartburn): Almagel, Rennie, Gastal. They dissolve the membrane ahead of time, and the active substance irritates the stomach and duodenum, neutralizes the laxative effect and leads to stagnation of feces and pain in the abdominal region.
• Cardiac glycosides: Digoxin and Celanide. The laxative greatly enhances the effect of these drugs.
• Furosemide, Prednisolone, Hydrochlorothiazide, carbenoxolone, corticosteroids, diuretics. With the simultaneous use of bisacodyl with the agent in question, potassium is rapidly washed out from the cells of the body, which increases the risk of seizures.
• Any drugs that slow down bowel movements (opiates).
• Medicines containing aluminum and psychotropic drugs.

Side effects

This remedy has a number of side effects. Despite the fact that it is not broad, but in terms of the severity of the manifestations, it must be taken seriously.

1. Addictive.
2. High likelihood of dehydration.
3. Creates potassium deficiency.
4. Disrupts bowel function.
5. Causes dyspeptic disorders and stomach pain.
6. Intestinal colic.
7. Lowers blood pressure.
8. Reduces the rate of metabolic processes.
9. Causes severe diarrhea, sometimes uncontrollable.
10. Weakness, muscle cramps.

Overdose

With an overdose of bisacodyl, there is an increase in side effects, sharp pains in the lower abdomen (especially in the elderly), and acute dehydration. If these phenomena take on a pronounced effect, antispasmodics can be used. In the absence of improvement, gastric lavage is performed, followed by rehydration.

After an overdose throughout the day, control over the serum potassium level is desirable.

Contraindications

• Acute pain in the abdominal region (appendicitis, cholecystitis, etc.);
• strangulated hernia;
• intestinal obstruction;
• bleeding;
• proctitis;
• peritonitis;
• Crohn's disease;
• acute period of hemorrhagic disease;
• intrauterine bleeding;
• cystitis;
• inflammation of the abdominal organs;
• any of the trimesters of pregnancy and lactation period;
• kidney disease;
• liver failure;
• hypovitaminosis of potassium;
• violations of water - electrolyte balance;
• allergic reaction.

Manufacturers and prices

Of the domestic pharmaceutical companies producing Bisacodyl, Nizhpharm, Akrihin and Altpharm, they have established themselves as manufacturers producing medicines of standard high quality. Among foreign companies, the products of the Hemofarm concern (Serbia) and the Bulgarian pharmaceutical company Balkanfarma are not inferior in characteristics.

This laxative is affordable. Thus, 30 Hemofarm tablets in pharmacies cost 25–32 rubles, 40 tablets produced by Akrihin - 36–40 rubles, 30 Balkanfarm tablets - 33-37 rubles. The cost in Internet pharmacies is usually slightly lower and starts at 23 rubles for 30 pieces. A simple calculation can establish that the cost of daily consumption is on average 0.15 rubles.

The price of Bisacodyl rectal suppositories is slightly higher: from 27.17 rubles. for 10 pcs. (Altpharm) up to 50 rubles. for 10 pcs. (Nizhpharm), that is, the minimum daily costs are 5.4 rubles.

Where can I buy

Bisacodyl is a remedy that can be purchased without a doctor's prescription. You can buy it at any pharmacy or online stores that sell drugs. When ordering via the Internet, you can compare prices and choose the cheapest forms, having read in parallel with the reviews of those who are losing weight. But in this case, it is imperative to familiarize yourself with the certificates from the manufacturers in order to be sure of the quality of the medicine, the reputation of the manufacturer and the responsible attitude towards working with customers of the Internet store itself.

Analogs

Among the analogues of this remedy are preparations both with the same active ingredient and on the basis of other active substances: Gutallax, Naturolax (powder), Regulax, Senadexin, Gutasil, Ritmil, Videx, Brokalax, Bisalax, Kontalax, Teralax, Pentalax, Spirolax, Oralax, Enterralax, Fenolax, Megalax, Alsilax, Ritmil, Alaxa, Pronolax, Laxorex, vaseline oil, glycerin candles.

Bisacodyl belongs to the group of laxatives that affect the digestive system and metabolic processes in the body.

Pharmaceutical companies produce two dosage forms of the drug:

• Bisacodyl tablets;
• Bisacodyl rectal suppositories.

The active ingredient of the medication: bisacodyl (bisacodyl).

Bisacodyl tablets are round and film-coated, which dissolves in the intestine. The color of the shell can vary from light yellow to yellowish green or orange yellow. Each tablet contains 5 mg of the active substance of the drug in terms of 100% dry matter.

Bisacodyl candles are white or cream-colored, cigar-shaped. Each suppository contains 10 mg of the active ingredient.

Pharmacological properties of Bisacodyl

Bisacodyl is a drug with a pronounced laxative effect. The active substance, getting into the large intestine and irritating its mucous membrane, as well as stimulating the nerve endings of the submucosa, has a stimulating effect on its peristalsis as a whole. In this case, bisacodyl is poorly absorbed from the gastrointestinal tract and is able to influence the absorption of electrolytes. As a result, the increased osmotic pressure in the intestinal lumen retains most of the fluid, the contents of the intestine soften, and its passage through the large intestine is greatly facilitated. In addition, due to the use of Bisacodyl, the volume of stool increases, which in itself helps to stimulate intestinal motility and facilitates the process of emptying it.

Under the influence of bacterial enzymes, bisacodyl is biotransformed in the colon to an active compound - diphenol, which, when passed through the liver for the first time, combines with glucuronic or sulfuric acid and then returns to the intestine through intestinal-hepatic circulation. Thanks to this process, the drug is able to affect the body for a longer period of time.

The effect of the use of Bisacodyl is noted within an hour after its administration in the form of a suppository and approximately six to eight hours after oral administration. Absorption of the active substance after intrarectal application of the agent is minimal. The absorbed substance undergoes a deacetylation process in the liver tissues, resulting in the formation of a phenolic derivative, which is subsequently excreted by the kidneys in the urine. The part of bisacodyl that remains in the intestine (in particular in the colon) is excreted along with the feces.

After taking Bisacodyl tablets, an insignificant part of the active substance (no more than 5%) is absorbed from the intestine and, having undergone the process of conjugation in the liver tissues, is included in the enterohepatic blood circulation, and then partially excreted with urine, and partially with feces.

Indications for the use of Bisacodyl

According to the instructions, it is advisable to prescribe Bisacodyl:

• For the symptomatic treatment of acute conditions of constipation;
• To eliminate chronic constipation in elderly patients, as well as in patients who are forced to keep to bed for a long time;
• To cleanse the intestines from the contents before carrying out certain diagnostic procedures;
• Before performing surgery;
• Before obstetric interventions;
• To facilitate the processes of defecation in the postoperative period;
• With intestinal atony, which developed against the background of a radical change in diet, as well as environmental factors;
• With severe cardiovascular diseases.

Contraindications

In accordance with the instructions, Bisacodyl is contraindicated:

• Patients with intestinal obstruction;
• People who have a hernia infringement;
• With acute inflammatory processes affecting the abdominal organs;
• In conditions characterized by potassium deficiency;
• With peritonitis;
• In conditions accompanied by bleeding from the organs of the gastrointestinal tract;
• With uterine bleeding;
• With cystitis;
• Patients suffering from spastic constipation;
• With acute proctitis;
• With acute hemorrhoids;
• Patients who have increased individual sensitivity to the components of the drug;
• Children under the age of two;
• With nausea and vomiting of unknown etiology.

With caution, tablets and suppositories Bisacodyl are prescribed to women during pregnancy and lactation, as well as to patients with a history of kidney and liver pathologies. Moreover, it is important to remember that between taking Bisacodyl in tablet form and taking drugs, the action of which is aimed at neutralizing gastric acid, as well as the use of milk and products prepared on its basis, it is necessary to maintain an interval of at least two hours. Also, while undergoing treatment with Bisacodyl tablets, you must consume a sufficient amount of water.

Interaction with other drugs

The simultaneous administration of this medication with drugs that help reduce the amount of potassium contained in the body can enhance the effect of the latter and provoke the development of a state of hypokalemia.

The effect of the use of Bisacodyl decreases if simultaneously taken with it:

• Drugs that retard the contents of the intestine;
• Anti-acid agents;
• Medicines containing aluminum as one of the ingredients;
• Anticholinergics;
• Psychotropic drugs;
• Cholestyramine.

Simultaneous reception with cardiac glycosides provokes an increase in sensitivity to them. This could be due to a possible potassium deficiency.

Method of administration and dosage

Bisacodyl in tablet form is prescribed 1-3 tablets at a time (before bedtime). Rectally, adults and children over fourteen years of age are recommended to administer 1 suppository per day.

The optimal daily dose for adults is 5 to 10 mg.

For children, the daily dose is determined depending on their age.

Overdose

The instructions for Bisacodyl indicate that exceeding the recommended dose of the drug can cause such unpleasant phenomena as:

• Pain in the lower abdomen;
• Signs of dehydration of the body (especially clearly, these symptoms can manifest themselves in the elderly and in children);
• Signs of irritation in the anal area (pain, fever, bleeding, etc.);
• Inflammatory processes, as a result of which the mucous membrane of the rectum is affected;
• Diarrhea, against the background of which muscle weakness, convulsive syndrome and arterial hypotension develop;
• Asthenia, orthostatic hypotension, various kinds of impaired coordination of movements (in older people taking the drug for a long period);
• Decrease in the level of potassium in the blood.