The use of nisin and natamycin in the production of dairy products. Preservatives Natamycin in the food industry

02.07.2020 Seafood dishes

136 rub


Baking sheet "You'll love", teflon, 33 cm x 40 cm

Baking sheet "You'll love" is made of fiberglass coated with Teflon.Teflon coating allows you to cook without adding oil.Teflon sheet is designed for use in gas and electric ovens, microwave ovens.It is used to line the baking sheet when baking and frying food.After To use it, it is enough to wipe it with a wet cloth and rinse it in warm running water.Material: fiberglass.
Sheet size: 33 cm x 40 cm.

179 rub


Baking paper "Paclan", 8 m x 38 cm

Baking paper "Paclan" is widely used in the household, both for baking and all kinds of dishes, and for storing products containing fats and moisture, such as butter, curd products, sandwiches, ready-made fish dishes and other products. The form does not need to be lubricated with oil, which prevents the baking from burning. Paper is made of environmentally friendly and absolutely harmless to health material.

Paper length: 8 m.
Paper width: 38 cm.

119 rub


Lid glass Nadoba "Mineralica", with silicone rim. Diameter 24 cm

The Nadoba "Mineralica" lid, made of tempered glass, has a silicone rim, thanks to which it fits perfectly to the dishes and ensures even temperature distribution inside it.
The lid has a convenient non-heating plastic handle.

869 rub


Rope for baking Tescoma "Presto", 40 m

Tescoma "Presto" rope is excellent for tying meatloaf, poultry, vegetables, baking, frying, boiling and steaming. Made of durable fiber, can withstand temperatures up to 250°C, suitable for all types of ovens, including microwaves.

324 rub


Straws for thick cocktails Fackelmann "Rio", 20 cm, 40 pcs

Wide tubes for thick Fackelmann "Rio" cocktails are made of food-grade non-toxic multi-colored plastic. The tubes don't leak. They will be able to fully realize your creative imagination when decorating cocktails and drinks. Your table will become bright and festive, and guests will be pleasantly surprised by the mastery of the hosts. Characteristics:

  • Material: polypropylene.
  • Tube length: 20 cm.
  • Tube diameter: 1 cm.
  • Package contents: 40 pcs.
  • Article: 54610.

    Fackelmann was founded in 1948 and is currently the world's largest supplier of household products. The company's product range includes products for a variety of customers. Fackelmann's products are made of various combinations of metal - stainless, chrome, nickel-plated and tin-plated steel, light and dark wood - beech and pine, plastic, acrylic, transparent, frosted and colored glass. With products "Fackelmann" your home will become more beautiful, cozier and much more comfortable!

  • 162 rub


    Set of bags for breakfast "Paclan", 17 cm x 24 cm, 50 pcs

    Paclan lunch bags made of food-grade polyethylene are used for food storage. A practical set of sachets that preserve vitamins, microelements, natural freshness and aroma of foodstuffs. Characteristics:

  • Material: polyethylene.
  • Package contents: 50 pcs.
  • Size: 14 cm x 24 cm.
  • Package size: 26.5 cm x 12 cm x 0.5 cm.
  • Manufacturer: Poland.
  • Article: 163510.
  • 50 rub


    Cast pan Neva Metal Cookware "Traditional" with non-stick coating, with removable handle, diameter 24 cm.

    Frying pan "Traditional" from a series of cast aluminum cookware with water-based non-stick coating. The non-stick coating is made on a water basis, belongs to the safest, fourth class according to GOST. Non-stick coatings are traditionally made WITHOUT the use of PFOA (perfluorooctanoic acid). Evenly heated due to the special design of the cast body according to the "golden section" principle, thick walls (4 mm) and an even thicker bottom (6 mm). Cooked food is especially delicious due to the specific thermal storage properties of the food-grade aluminum-silicon alloy. The body, cast by hand, is practically not subject to deformation even with strong heating. For convenience, there is a removable handle.

    The ware is suitable for use on gas, electric and glass-ceramic stoves; freezer and oven; it can be washed in the dishwasher. Characteristics:

  • Material: aluminum.
  • Frying pan diameter: 24 cm
  • Wall height: 6.2 cm
  • Handle length: 20 cm
  • Bottom diameter: 18 cm
  • Wall thickness: 4 mm.
  • Bottom thickness: 6 mm.
  • Manufacturer: Russia.
  • Package size: 44 cm x 25 cm x 6.2 cm.
  • One of the most famous and most harmless food preservatives is natamycin, another name for which is pimaricin, or food additive E235. By nature, it is a powerful antibiotic of natural origin. The synthesis of a substance occurs in the process of vital activity of certain types of microorganisms.

    Natamycin is a substance with a pronounced anti-mold and antifungal property, recognized as safe for humans at the world level. Even at low concentrations, this food additive is able to inhibit the growth and development of a wide range of known fungi and mold cultures, while not affecting beneficial microorganisms. Due to this specificity of action, pimaricin is known as a popular ingredient in cheeses and processed meat products. But the food industry is not the only industry in which the additive has found application.

    Chemical characteristics of natamycin, its origin

    The substance belongs to polyene antifungal agents of the macrolide type. In appearance, it is a white or cream-colored crystalline powder that has no taste or smell. The preservative is very poorly soluble in, forming an inhomogeneous cloudy white suspension, and does not dissolve in most organic solvents. It has good solubility in and also in the presence of a small amount of demethyl sulfoxide or glacial.

    The solubility of a substance varies greatly depending on the level of acidity: at a pH level of 3 to 9, it greatly increases, while its activity against microorganisms decreases.

    At room temperature, natamycin is highly stable, which can be further enhanced by increasing humidity levels. In the dry state, the active powder can withstand temperatures up to 100 degrees Celsius, but for a short time. However, if the substance is exposed to temperatures above 50 degrees for longer than 24 hours, its activity decreases.

    The level of acidity affects not only the solubility, but also the strength of action of pimaricin - at a pH level of 5-7 it will be the most powerful, from 3 to 5 or from 7 to 9 - it weakens by 8-10 percent. If the pH is more than nine or less than three, the activity of the preservative drops by about 30 percent.

    In addition, the additive is also sensitive to sunlight: exposure to it can reduce its activity.

    E235 can react with various oxidants, such as peroxide or chlorine dioxide, as a result of which its effect is weakened. In this case, manufacturers use something like .

    The stability of the component may be impaired by the influence of some heavy metals: lead, mercury or. This factor must be taken into account when choosing a packaging for storing a substance.

    The E235 additive is obtained microbiologically by fermenting it from cultures of streptomycete mold fungi. The resulting active substance is concentrated, crystallized, then dried and, usually in a ratio of 1/1, mixed with, which plays the role of a neutral carrier.

    The most basic property is antifungal and preservative, which is why it is used as a preservative in various industries. A preservative extends the shelf life of finished products or raw materials.

    The mechanism of action of the substance

    As an antibiotic, natamycin is about 500 times more potent than sorbic acid. Most harmful microorganisms are affected by the additive diluted to a concentration of 1-6 parts per million. Literally several types of mold require a higher concentration of the active substance - 10-25 parts per million.

    The antibiotic acts on the sterols in the cell wall of fungi or mold, binding them and thereby causing membrane malfunction. As a result, the cell loses important metabolites and dies. It is for this reason that the substance does not act on bacteria - there are no sterols in the walls of their cells.

    The use of natamycin in the food industry

    Along with the pharmaceutical industry, the food industry consumes a significant amount of the produced E235 preservative. The main areas of application of the additive:

    • surface treatment and spraying of whole and sliced ​​cheeses;
    • surface treatment of fish and meat products;
    • addition to dairy products ( , );
    • adding to the pulp of fruits and fruit juices;
    • use in the process of cooking canned dairy products, fish raw materials, caviar, minced meat, fish pastes.

    Technologies for the use of natamycin for cheese processing

    In the process of making cheeses, the component is practically indispensable: it is used to suppress mold in mature cheeses. At the same time, natamycin cannot be applied directly to the raw material; only the surface of the product can be treated with it.

    The main advantage of the substance over other types of preservative is that it is able to destroy mold microorganisms on the surface of the cheese, without affecting the process of its bacterial maturation.

    There are several ways to process cheese products:

    • adding 0.05% natamycin to the composition of the shell;
    • immersion of salted cheese in the liquid form of the substance at a concentration of 0.05-0.28% for a short period of time (no more than 4 minutes);
    • spraying a suspension of a similar concentration onto the cheese casing or the product cut into pieces.

    The result of the use of the substance is an increase in the yield of finished products without traces of harmful microorganisms and spoilage of the cheese that they cause, as well as an improvement in the appearance and quality of the product, and an extension of its shelf life.

    The brine used for dipping cheeses may also contain pimaricin. 30-50 grams of preservative are added per 1 ton of liquid. Such an amount, firstly, is sufficient to suppress the growth and development of harmful fungi and mold, and secondly, it meets international requirements regarding the content of the E235 additive in food. To maintain the concentration of the substance in the future, every 2 weeks another 10 g of natamycin is added per 1 ton of brine.

    Surface treatment occurs with the help of a suspension, which is prepared in this way: 2-4 g of preservative is added to 1 liter of water with a temperature of not more than 15 degrees Celsius. The head of cheese is dipped into the resulting liquid, dried and packaged.

    Such an aqueous solution can be sprayed on the surface of cheeses, which allows you to extend their shelf life.

    An important technological requirement in the process of making cheese is that pimaricin should not penetrate deeper than 5 mm into it.

    How is preservative E235 used for meat and fish

    Products are processed similarly to cheese - they can be dipped in a suspension of natamycin or sprayed, and the shell can also be processed by soaking in a solution of the substance. The permissible concentration of the additive is not more than 4 mg per 1 cm 3. Thus, it is possible to save such food from the formation of mold and the reproduction of fungi:

    • sausages and sausages;
    • dried, dried fish;
    • grilled meat;
    • smoked meat, poultry and fish.

    The most common method of “preserving” sausages and frankfurters from the harmful effects of microorganisms is casing processing. Thanks to this technology, the antibiotic does not get deep into the food. The shells are soaked in a suspension of the additive, which settles on their surface. As a result, spoilage of the product above and below the casing is prevented. Shells of natural origin are soaked for about 2 hours, synthetic - from 20 to 60 minutes.

    Dipping of freshly prepared sausages takes place in a suspension with a temperature of 20-30 degrees Celsius. The concentration of the solution is not more than 2 g of natamycin per liter of water, in addition, sodium chloride (8-10%) is added to it. For spraying, a more concentrated mixture is used - 3-4 g of active ingredient per 1 liter of water. Sodium chloride is also used here.

    Other products in which the additive E235 may be found

    In addition to cheeses, sausages and sausages, the preservative is used to process:

    • (concentration of 15 particles per 1 million reliably protects the product from mold processes);
    • bakery products (a suspension of 150-200 ppm is applied to the surface of finished products or raw dough);
    • fruit juices (in, the substance inhibits the fermentation process and prevents the reproduction of yeast);
    • canned foods;
    • vinegar, (suppresses the growth and reproduction of yeast and mold);
    • confectionery.

    Another area in which natamycin cannot be dispensed with is pharmaceutical. This substance is active in various medical preparations aimed at treating various forms of fungal diseases, and is used in ointments, creams, suppositories and tablets.

    Benefit and harm to humans

    According to the results of scientific research, the E235 additive does not have a toxic effect on the human body. The main spectrum of its action is the fight against fungal diseases:

    • fungal otitis;
    • candidiasis of the skin and nails;
    • intestinal candidiasis;
    • diseases of the oral cavity associated with the activity of fungi;
    • thrush.

    To date, there is no officially confirmed data on the possible oncogenicity or mutagenicity of the substance. The only danger that it can pose is the negative consequences of an overdose.

    The normal daily dose of pimaricin is 0.3 mg per 1 kilogram of adult weight.

    The concentration of the additive in food products is insignificant, and it is almost impossible to get a dose exceeding the norm with them, which cannot be said about medicines. An amount of more than 500 mg per 1 kg of body can have a poisoning effect with corresponding symptoms - nausea, vomiting, diarrhea. In this case, it is necessary to wash the stomach of the victim, in severe cases, seek medical help.

    It should also be taken into account that the substance is an antibiotic, and its entry into the body, including with food, can adversely affect the microflora of the stomach and intestines, causing disturbances in their work. For these reasons, children are not recommended to eat food with an additive in the composition. With caution, it should be treated by people with diseases of the digestive tract.

    Natamycin is not only a food preservative, but a powerful antibiotic, a means to combat fungal and mold microorganisms. It should be noted that a number of states of the European Union, the USA and Canada have banned the use of the E235 additive in food products within their territories. In Ukraine and Russia, there is no such ban, so the production of cheeses, sausages, canned food, juices, confectionery products, alcoholic beverages like fruit or berry wine and beer often resorts to its help to prevent food spoilage. The spectrum of action of pimaricin is fungi, yeast and mold cultures, while it has no effect on bacteria, so it cannot interfere, for example, with cheese ripening processes. In small doses, the food preservative E235, in general, does not harm a person and is not hazardous to health.

    The pharmaceutical industry uses natamycin as the active ingredient in some antifungal drugs, some of the most popular being Pimafucin and Ecofucin. With their help, candidiasis, fungal otitis media and other fungal infections of the skin, nails and mucous tissues are treated. The additive has shown itself to be a powerful antibiotic with a depressing effect on pathogens.

    E235 is a substance that benefits in several areas.

    Firstly, pimaricin (the full name of the compound) helps keep food fresh, and secondly, it is used as an active ingredient in medicines.

    There are several other names for E235, or pimaricin, on food labels:

    • natamycin;
    • mitrotsin;
    • pimaricin, natamycin (English, German);
    • pimaricine, natamycine (fr.).

    Substance type

    You can read about the effect of potassium nitrate (E252) on the human body.

    Benefit or harm

    If you follow the recommended dosage, then the supplement is well tolerated by the body, it is not addictive.

    With the abuse of pimaricin, the maximum doses for which are indicated in the table above, symptoms of food poisoning occur, manifested by vomiting, nausea, and diarrhea.

    Is it possible to do without antibiotics when storing food? Can! Homemade sausage was stored in pots filled with lard, which prevented air from entering. Mustard was also added there, which prevented the delicacy from spoiling. And Lapland cheese was dried and stored with grain. True, a special cooking technology also mattered here. Such a product remained fresh for years and was considered a delicacy, which, for lack of money, was paid to workers.

    It should also be remembered that E235 is an antibiotic, and together with the pathogenic flora, it kills beneficial bacteria. Therefore, the use of pimaricin should be strictly dosed.

    Natamycin (Natamycin, pimaricin, pimaricin, pimafucin, E235) is an antifungal antibiotic.

    It is used for the treatment and prevention of non-invasive intestinal candidiasis, infections of the skin and mucous membranes caused by Candida or other sensitive yeasts, yeast-like fungi or dermatophytes (balanoposthitis, otomycosis).

    Also used as a preservative in the food industry as food additive E235.

    Natamycin or pimaricin (food additive E235) - a strain produced during the fermentation process by bacteria Streptomyces natalensis. Additive E235 is slightly soluble in alcohol and water. However, natamycin is quite effective at very low concentrations. By nature, natamycin is a natural antifungal agent and is used in the food industry as an E235 preservative additive.

    Additive E235 is non-toxic, but at high concentrations (more than 500 mg / kg of body weight) it can cause nausea, vomiting, and diarrhea. Being an antibiotic, the E235 additive is added to food in a strictly limited amount due to the properties of antibiotics to kill not only harmful fungi and bacteria, but also microorganisms involved in the vital processes of the human body.

    For decades, the preservative E235 has been used in the food industry to prevent the development of fungi in dairy products, meat and other food products. Additive E235 can also be used in confectionery: cakes, pastries, biscuits. In addition, the additive E235 is used in the manufacture of cheeses as its shell. As a result of surface treatment (irrigation of the surface or immersion in a solution of the finished product), the E235 preservative remains strictly on the surface of the cheese. In some countries, the use of natamycin for the surface treatment of sausages is allowed.

    In addition to the food industry, natamycin is widely used in medicine as a polyene macrolide antibiotic for the treatment of fungal diseases of the skin, mucous membranes, and gastrointestinal tract. Natamycin is widely used in the treatment of otitis externa; skin and nail candidiasis; ringworm; intestinal candidiasis; fungal diseases of the oral cavity, such as acute pseudomembranous and acute atrophic candidiasis in patients with cachexia and immune deficiency and other diseases caused by pathogenic yeast fungi. Tablets, suspensions, creams, suppositories are made from natamycin.

    In many countries, the use of the E235 additive in the food industry is strictly prohibited. In Ukraine and Russia, pimaricin is approved for use in food products as a preservative additive E235.

    Useful properties, as well as the harm of food preservative E235 Natamycin (pimaricin) has been scientifically proven and substantiated as a result of a number of studies, experiments and laboratory experiments. For this reason, the food preservative E235 Natamycin (pimaricin) was assigned the status of a "dangerous" (in large quantities) food additive for human life and health. However, at present, the food preservative E235 Natamycin (pimaricin) continues to be used in the process of manufacturing food products in the European Union, the USA, Japan, Canada, Asia, as well as in the Russian Federation and neighboring countries.

    Harm food preservative E235 Natamycin (pimaricin)

    True, given the possible negative consequences of the harm of the food preservative E235 Natamycin (pimaricin) for the human body, doctors have established the maximum allowable standards for the content of dangerous chemically active substance natamycin in food products. In addition, one should remember the maximum allowable daily dosages of food products that contain the food preservative E235 Natamycin (pimaricin) in their chemical composition. It is believed that the body of an adult and healthy person can easily tolerate up to 0.3 mg / kg of body weight.

    In case of an overdose of pimaricin or natamycin, undesirable negative consequences may appear in the form of allergic reactions or rashes on the skin. Unlike many other E235 food preservatives, Natamycin (pimaricin) does not have a toxic or carcinogenic effect. However, the biologically active substance natamycin or pimaricin, which is included in the chemical composition of the food preservative E235 Natamycin (pimaricin) has such powerful antibacterial abilities that it destroys not only pathogenic, but also beneficial bacteria and microorganisms.

    The exclusivity of the benefits, as well as the main harm of the food preservative E235 Natamycin (pimaricin) lies precisely in the distinctive antibacterial abilities of the chemical compound. Doctors believe that you should eat foods that contain the food preservative E235 Natamycin (pimaricin) as little as possible. Preservative E235 refers to synthetic and derivative chemical compounds. Streptomyces natalensis bacteria undergo a fermentation process, as a result of a chemical reaction, the biologically active substance natamycin is released, which is part of the E235 preservative and determines the exceptional properties and characteristics of the final chemical compound.

    It is noteworthy that natamycin refers to substances of natural origin. The main feature of the food preservative E235 Natamycin (pimaricin) can be considered the ability of a chemical to prevent the emergence and development of pathogenic bacteria, as well as fungi. Most often, the food preservative E235 Natamycin (pimaricin) is used in the manufacturing process of meat products and semi-finished products, fermented milk products, as well as sweets and confectionery.

    In addition, the food preservative E235 Natamycin (pimaricin) has found wide application in the pharmacological industry. A food preservative is included in most medicines that help in the treatment of various types of diseases of the gastrointestinal tract and skin. Natamycin helps in the treatment of dermatitis, candidiasis and other diseases resulting from the harmful effects of yeast pathogens.



    Natamycin(food supplement E-235) is a strain obtained from the culture liquid of Streptomyces natalensis, slightly soluble in alcohol and water.

    Additive E-235 non-toxic, but at high concentrations (more than E-500 mg / kg of body weight) can cause nausea, vomiting, diarrhea. As an antibiotic supplement E-235 It is added to food in a strictly limited amount due to the properties of antibiotics to kill not only harmful fungi and bacteria, but also microorganisms involved in the vital processes of the human body.

    It is widely used in medicine as a polyene antibiotic of the macrolide group for the treatment of fungal diseases of the skin, mucous membranes, and gastrointestinal tract. It is almost not absorbed from the surface of the skin, mucous membranes and from the gastrointestinal tract. Widely used in the treatment of otitis externa; skin and nail candidiasis; ringworm; intestinal candidiasis; fungal diseases of the oral cavity, such as acute pseudomembranous and acute atrophic candidiasis in patients with cachexia and immune deficiency and other diseases caused by pathogenic yeast fungi. Tablets, suspensions, creams, suppositories are made from this substance. Natamycin non-toxic, but can sometimes cause nausea and diarrhea.

    In the food industry, it is used as a preservative, for example, in the manufacture of cheese, as its shell. Being an antibiotic, it is added in a strictly limited amount, and for the most part, due to poor solubility in water, it remains strictly on the surface of the cheese. In many countries, its use in the food industry is strictly prohibited.

    For decades a preservative E-235 used in the food industry to prevent the development of fungi in dairy products, meat and other food products. Additive E-235 can also be used in confectionery: cakes, pastries, biscuits. In addition, the additive E-235 used in the manufacture of cheese (shell). As a result of surface treatment (irrigation of the surface or immersion in a solution of the finished product), the preservative E-235 remains strictly on the surface of the cheese. In some countries, the use of natamycin for the surface treatment of sausages is allowed.